Overview:

GenDx NGS HLA Typing Solutions provide high-resolution Human Leukocyte Antigen (HLA) typing solutions designed for transplantation diagnostics and immunogenetics laboratories. Using next-generation sequencing (NGS) technology, GenDx enables accurate and comprehensive characterization of HLA genes to support stem cell and organ transplantation matching, helping reduce transplant rejection risks and improve patient outcomes.

The GenDx portfolio includes amplification kits, library preparation systems, sequencing workflow solutions, and advanced analysis software compatible with major sequencing platforms including Illumina, Oxford Nanopore Technologies (ONT), Ion Torrent, and PacBio. Their workflows are designed for flexibility, scalability, rapid turnaround time, and high typing accuracy across multiple HLA loci.

Features:

Comprehensive HLA Coverage

• Supports typing of major HLA loci including HLA-A, B, C, DRB1, DRB3/4/5, DQA1, DQB1, DPA1, and DPB1.
• Whole-gene amplification enables high-resolution allele discrimination.

Multi-Platform Compatibility

• Compatible with leading sequencing platforms:
  • Illumina
  • Oxford Nanopore Technologies (ONT)
  • Ion Torrent
  • PacBio

Flexible Workflow Options

• Single-locus and multiplex amplification workflows available.
• Solutions for both short-read and long-read sequencing applications.
• Supports low-throughput to high-throughput laboratories. 

Rapid Turnaround Time

• NGS-Turbo workflow delivers high-resolution HLA typing in approximately 3 hours from sample to result.
• Fast PCR amplification and simplified library preparation reduce workflow time. 

User-Friendly Software

• NGSengine® software provides:
  • Automated locus assignment
  • Read alignment
  • Read phasing
  • Genotyping analysis
• Intuitive interface with regular software updates and customizable settings.

CE-IVD and RUO Availability

• Multiple products available as CE-marked IVD and Research Use Only (RUO) formats to support clinical and research laboratories.

Advantages:

High Accuracy and Resolution

• Enables precise allele-level HLA typing critical for transplant compatibility assessment.
• Reduces ambiguities commonly associated with traditional typing methods.

Improved Transplant Outcomes

• Accurate donor-recipient matching helps reduce graft-versus-host disease (GVHD) and transplant rejection risks.

Faster Decision-Making

• Rapid workflows support urgent transplantation cases where turnaround time is critical.

Scalable Laboratory Operations

• Supports workflows ranging from single-sample processing to high-throughput batch testing.
• Flexible reagent and indexing options simplify laboratory scaling.

Streamlined Workflow

• Integrated amplification, library preparation, and analysis solutions minimize manual handling and reduce workflow complexity.
• Compatible with automated and manual laboratory processing.

Reliable and Intuitive Analysis

• Automated software interpretation minimizes user intervention and enhances consistency in reporting.