Genexus Integrated Sequencer

Overview:
IGB offers the Genexus Integrated Sequencer, an automated next-generation sequencing (NGS) platform designed to streamline the entire targeted sequencing workflow from purified nucleic acid to final report. With a single touchpoint and approximately five minutes of hands-on time, the system integrates library preparation (including cDNA synthesis), template preparation, sequencing, primary data analysis, and variant reporting into one seamless process.

Built on Ion Torrent semiconductor sequencing technology, the Genexus system uses the GX5 Chip, which features four independent lanes. Each lane can generate 12–15 million reads and can be used individually or together, providing flexibility in throughput and sample batching. The integrated Genexus Software further simplifies operations by unifying workflow setup, analysis, and reporting within a single platform.

Features:
  • Enables rapid turnaround with nucleic acid to report in a single day
  • Fully automates library preparation, sequencing, and data analysis including variant calling
  • Flexible throughput with up to 32 library reactions per run in increments of four
  • Four-lane GX5 Chip allows simultaneous processing of multiple assays
  • Reduces operational complexity with pre-filled reagents and minimal hands-on time
  • Integrated vision system verifies reagent placement and minimizes user error
  • Unified software ecosystem for workflow setup, analysis, and reporting with version flexibility

Genexus Dx Integrated Sequencer

Overview:
IGB offers the Genexus Dx Integrated Sequencer, an automated next-generation sequencing (NGS) platform designed specifically for clinical laboratories, combining ease of use with regulatory compliance. The system enables a complete nucleic acid-to-report workflow within a single day, requiring only a single touchpoint and approximately 10 minutes of hands-on time.

The platform integrates library preparation, sequencing, data analysis, and variant reporting into one streamlined workflow using pre-filled consumables, making advanced sequencing accessible to laboratories with varying levels of expertise. Built on Ion Torrent semiconductor sequencing technology, the system utilizes the GX5 Dx chip with modular consumables that support flexible throughput from small to large batch sizes.

Genexus Dx Software supports both IVD assays and assay development for clinical research, offering versatility within a compliant framework. The system is designed for qualitative targeted sequencing of human DNA or RNA from FFPE tumor tissue or plasma samples, supporting precision medicine applications. It is a Class II medical device listed with the US FDA and complies with EU IVDR 2017/746 regulations.

Features:
  • Completes nucleic acid-to-report workflows in a single day with ~10 minutes hands-on time
  • Fully automates library preparation, sequencing, analysis, and variant calling
  • Scalable throughput with up to 32 library reactions per run using GX5 Dx chip
  • Flexible operation supporting IVD assays and clinical research workflows
  • Modular consumables for efficient small and large batch processing
  • Integrated vision system provides real-time feedback to prevent user errors
  • Designed for regulatory compliance including US FDA Class II listing and EU IVDR