Overview:
IGB offers Twist’s Exome 2.0 Panel, which has been carefully designed to help alleviate common sequencing pitfalls and provide researchers with high uniformity, on-target rate, and target coverage; all while delivering on the most updated set of protein-coding and disease-relevant content, including noncoding variants. Twist also offers Exome 2.0 plus Comprehensive Spike-in panels for additional content with improved coverage of clinical genomic databases.
Specifications:
• Exome 2.0
• 36.5 Mb of targets
• 99% of targets covered at >20x
• Exome 2.0 plus Comprehensive Spike-in
• 37.6 Mb of targets
• Includes an additional 1.14 Mb of improved coverage of key gene targets
Features:
Coverage that makes a difference
• Exome 2.0 panel covers essential protein-coding regions and noncoding genes
• Addition of the Comprehensive Spike-in enhances coverage of key genes and ClinVar content
• Designed based on major genetic and clinical databases
• Includes curated content relevant to human disease research
Robust performance
• Duplexed DNA probe design ensures high uniformity of target enrichment
• Optimized design strategies improve on-target rates and sequencing efficiency
• All panels undergo NGS QC for consistent and reliable performance
Adaptable to your needs
• Base Exome 2.0 panel can be customized with additional content
• Compatible with multiplex target enrichment workflows
• Supports flexible sequencing timelines including overnight and same-day workflows across multiple platforms
