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One single assay for comprehensive coverage of relevant myeloid mutations
Current methods for the analysis of hematological malignancies often involve multiple sequential tests and laborious workflows. Adoption of next-generation sequencing (NGS) into clinical research laboratories has created an unprecedented opportunity to profile the multiple relevant driver genes in myeloid malignancies in a single test.
The Ion Torrent Oncomine Myeloid Research Assay is a comprehensive, targeted NGS assay designed to assist in the understanding of myeloid cancer. Specifically, it interrogates relevant DNA mutations and fusion transcripts associated with myeloid disorders in a quick and easy NGS run. Our panel is comprised of 40 key DNA target genes and 29 driver genes in a broad fusion panel (Table 1) to cover all the major myeloid disorders: acute myeloid leukemia (AML), myeloid dysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), and juvenile myelomonocytic leukemia (JMML).
Benefits
- Ease of use—one simple, robust workflow with all mutations encapsulated in two DNA and one RNA pool
- Effective designs—great coverage of challenging targets such as CEBPA and internal tandem duplications of FLT3 (FLT3-ITDs)
- Flexibility—verified with blood and bone marrow samples on the Ion PGM and Ion GeneStudio S5 systems, with manual and automated library preparation
- Speed—from samples to answers in <3 days, with up to four samples on an Ion 318 Chip or twelve on an Ion 530 Chip
Oncomine Myeloid Research Assay
