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Human Plasma-Like Medium (HPLM)

Create physiologically relevant cell culture models with HPLM

Gibco Human Plasma-like Medium (HPLM) is formulated to resemble the natural cellular environment found in the body, mimicking the metabolic profile of human plasma. 

Widely used, synthetic cell culture media, including MEM, DMEM, RPMI 1640, and DMEM/F-12 contain glucose, amino acids, vitamins, and salts at concentrations that, in large part, do not reflect those found in human plasma. These media also lack additional plasma components needed to mimic the metabolic profile of human plasma. When studying cancer and other diseases, results with more physiological relevance will enable researchers to help improve their understanding of human function and illness.

The HPLM solution

Gibco HPLM contains the same salt concentrations found in human plasma, as well as the same concentrations of over 60 polar metabolites, such as amino acids, nucleic acids, sugars, and small organic acids. In resembling the natural cellular environment found in the body, HPLM helps provide researchers the ability to study the impact of physiologically relevant cell media on their specific applications.

HPLM supplemented with fetal bovine serum (FBS) can support cell growth and viability comparable to those of conventional FBS-supplemented basal media formulations. For most cell lines, adaptation is not required to transition from conventional medium to HPLM.

HPLM is beneficial to your cell culture experiments in several ways:

  • Physiologically relevant—formulated with more than 60 polar metabolites and salt concentrations that resemble the natural cellular environment found in the body
  • Peer reviewed—extensive research publications completed using HPLM formulation
  • Easy to use—direct replacement for your current media when supplemented with FBS

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